Double Strand Breaks

Different techniques are available with different sensitivity to detect DNA damages such as double strand breaks , single strand breaks , delay DNA repair sites and alkali labile sites .

目前采用的彗星实验有多种，可以检测诸如DNA双链断裂、单链断裂、碱不稳定位点等多种类型的DNA损伤。

Study on DNA double strand breaks induced by radiation of γ - ray

γ射线辐射引起DNA双链断裂的研究

DNA double strand breaks are important lesions induced by irradiations .

辐射过程引起的生物细胞的DNA双链断裂是一种很重要的细胞损伤过程。

Relationship between the Constitutes of DNA Double Strand Breaks and Scavenging Capacity

DNA双链断裂的组成与自由基清除效能的关系

DNA single and double strand breaks of peripheral blood lymphocytes in mice induced by γ rays irradiation

单细胞凝胶电泳检测外照射诱导DNA单链断裂和双链断裂

Measurement of DNA Double Strand Breaks in Mammalian Cells After Ionizing Radiation by Pulsed Field Gel Electrophoresis

用脉冲电场凝胶电泳检测电离辐射所致哺乳动物细胞DNA双链断裂

Conclusions : 1 . PFGE is a sensitive method in analyzing fragmentations of DNA double strand breaks .

结论1.脉冲场电泳是分析DNA双链断裂的敏感方法。

The reduction of Ku after reperfusion may be the main reason that the DNA double strand breaks cannot be repaired in the ischemic region .

脑缺血再灌注早期，神经元Ku蛋白表达下降，可能是导致双链断裂的DNA无法得到修复的机制之一。

Methods Neutral single-cell gel electrophoresis was used to detect the effects of low dose radiation on DNA double strand breaks of peripheral blood lymphocytes in tumor-bearing mice after radiotherapy .

方法采用中性单细胞凝胶电泳检测低剂量辐射对荷瘤鼠放疗后外周血淋巴细胞DNA双链断裂的情况。

Moreover , exogenous agents , such as ionizing radiation and some chemicals can result in chromosome translocation and tumorigenesis because of their role on induction of DNA double strand breaks .

此外，外界因素，如电离辐射和某些化学药物等因素使DNA双链断裂，也可能导致染色体转位和癌变。

DNA double strand breaks ( DSBs ) induced by ion beams of gel electrophoresis experiment has shown positive linear with dose , i.e. , double strand breaks will increase as the dose increased .

分子生物学技术&电泳技术分析结果表明，离子辐射造成的DNA双链断裂（DSB）与粒子剂量呈线性正相关关系，即随着粒子剂量值增大，DSB量也逐渐上升。

It is reported that the gene at fragile site is susceptible to DNA double strand breaks and misrepair , so it could be the target of damage in mismatch repair deficient tumors .

有报道指出位于脆性位点的基因由于对DNA双链断裂及错误修复较为敏感，因而可能在错配修复缺陷肿瘤中成为损伤的靶目标。

Pulsed field gel electrophoresis has been applied to compare the sensitivity of B16 cells and their DNA molecules in the induction of DNA double strand breaks ( DSB ) by 50 MeV / u 12 C 6 + beam .

用倒转脉冲场凝胶电泳（PIGE）比较研究了50MeV/u12C6+辐照小鼠B16黑色素瘤细胞及其脱蛋白DNA分子，从而诱导DNA双链断裂（DSB）的辐射敏感性。

Distribution of Fragmentations of Radiation Induced DNA Double - strand Breaks

辐射致DNA双链断裂碎片分布研究

Dose - rate effects on the induction of DNA double - strand breaks with heavy-ion irradiation

重离子辐照诱导DNA双链断裂的剂量率效应

Fragmentation in DNA double - strand breaks

射线引起DNA双链断裂的统计分布